Senior Scientist - Cell Line Development

Senior Scientist - Cell Line Development

Job Title: Senior Scientist - Cell Line Development
Contract Type: Permanent
Location: Oxford
Salary: Competitive - Dependent on Experience Plus Excellent Benefits
Start Date: 2018-04-18
Reference: 15840 JH
Contact Name: James Hume
Contact Email:
Job Published: April 18, 2018 16:35

Job Description

James Hume is recruiting for a Senior Scientist – Cell Line Development to join an ambitious company who are at the forefront of synthetic biology and its application to the discovery, development and manufacture of Biologics, Cell & Gene Therapies.  This is a senior role within their laboratories that offers excellent longer-term career progression with exposure internally and with external stakeholders.  You will be expected to drive forward and lead specific projects from the bench which for this role will be focused on setting up and operationally leading CHO based cell lines for the manufacture of therapeutic proteins.

Job Summary

The Senior Scientist role’s purpose is to lead the setting up of and then operationally leading CHO based cell line development for the expression of therapeutic proteins.  This is a growing area for the company and is focused on developing cell lines for protein manufacture, the optimisation of cell growth conditions, and the genetic manipulation of cell lines for example.  Working on both internal development and commercial projects at the same time using you expertise to push them forward. 

This role is visible within the company because you will be interacting with protein engineering, expression and process development groups.  As well as with external stakeholders when working on external development projects alongside internal R&D projects.  As a Senior Scientist, you will be expected to drive forward and lead assigned projects from the bench and provide support to more junior colleagues within the group.  The ability to show commitment to scientific development and a commitment to innovation are essential for this role.

The Company

The company are at the cutting edge of the use of Synthetic Biology with a platform technology that enables them to engineer DNA which is a unifying theme across all their services – DNA design, expression system optimisation, cell line development and with a focus on viral delivery systems. 

They are going through a continued period of expansion due to the demand of their services from industry as well as after entering some major longstanding partnerships.  In addition to this they have other technologies under development after securing funding that will further enhance the portfolio of services they can offer.   They have an excellent culture where staff are all working closely together with the opportunity of rapid promotion as part of their culture and provide the chance to learn new skills.  In addition to the career path they are conscious of the work team members put in and because of this arrange regular events outside of work, away days and other events internally.

Desired Skills and Experience

You will need an MSc or PhD for this opportunity combined with academic or commercial experience, commercial experience is an advantage to your application.  You will need to have experience of working with mammalian suspension cell lines that includes generating stable and clonal lines.  As well as the generation of genetic constructs for protein expression.  Additionally, you will need experience of flow cytometry / FACS, q PCR / ddPCR, and assays to assess the product quality attributes e.g. ELISA, MS, HPLC.  Experience of working to a quality system such as GLP or GMP or ISO is advantageous to your application.


In addition to a competitive salary, the company offers an excellent benefits package including:

  • 25 days Annual Leave plus Bank Holidays
  • Pension with matched employer contribution to 7%
  • Health Insurance
  • Group Life Cover
  • Child Care Voucher Scheme
  • Glasses Vouchers

Modern, welcoming working environment