Bioinformatician - NGS

Bioinformatician - NGS

Job Title: Bioinformatician - NGS
Contract Type: Permanent
Location: Oxford
Salary: Up to £38,000 plus excellent benefits
Start Date: 2018-08-13
Reference: 15956 JH
Contact Name: James Hume
Contact Email:
Job Published: August 31, 2018 17:01

Job Description

James Hume is recruiting for a Bioinformatician with experience of Next Generation Sequencing to join an ambitious company who are at the forefront of synthetic biology and its application to the discovery, development and manufacture of Biologics, Cell & Gene Therapies.  This role is to be part of their multi-disciplinary Bioinformatics team that works in close collaboration with wet lab scientists on both commercial and internal platform development programmes.  The Bioinformatician NGS is to be responsible for the analysis of NGS data for the planning, interpretation, evaluation and visualisation of results for projects with an NGS component.

The Company
The company are at the cutting edge of the use of Synthetic Biology to streamline the discovery, development and production of biologics, cell & gene therapies. Their approach combines cutting edge use of bioinformatics taking advantage of algorithms and other tools that drive forward the rational designs of complex biological systems at the DNA level. These are then assembled on their automated platform technology which enables them to develop systems for the discovery, engineering, and production of antibodies, viral vectors, packaging & production cell lines for lentivirus and AAV manufacture, CRISPR libraries and CRISPR engineering.

They are going through a continued period of expansion due to the demand of their services from industry as well as after entering some major longstanding partnerships.  In addition to this they have other technologies under development after securing funding that will further enhance the portfolio of services they can offer.  They have an excellent culture where staff are all working closely together with the opportunity of rapid promotion as part of their culture and provide the chance to learn new skills.  In addition to the career path they are conscious of the work team members put in and because of this arrange regular events outside of work, away days and other events internally.

Job Summary:
The purpose of the Bioinformatician NGS is to design, implement and run software pipelines for analysing next - generation sequencing data.  You will be working as part of a multidisciplinary team comprising of scientific programmers, infrastructure engineers, and web app developers on both internal and commercial research projects.

You will be responsible for building data processing pipelines for targeted re – sequencing, whole genome sequencing and differential expression analysis experiments.  Working in collaboration with wet lab scientists in the planning, interpretation, evaluation, and visualisation of results for any projects with NGS components.  You will also be working closely in-house software engineers to integrate interfaces for the running of these pipelines into their web based LIMS.

This is a creative position where you will be working on cutting edge novel technologies, using your technical ability to deliver results for projects.  Working with like-minded scientists in an innovative and forward thinking environment.  Added to this is the chance to develop your career further as they continue to expand linked with their culture of providing the platform for the development of employee’s careers.

Desired Skills and Experience:
You will need an MSc or equivalent in bioinformatics, computational biology, computer science or related field with commercial and / or academic experience. 

In addition, you will need:

  • Programming experience of Python, Perl, Java and R
  • Experience with associated numerical analysis libraries e.g. NumPy for Python, ND4J for Java. 
  • Experience with NGS datasets, preferably Illumina Paired end, PacBio, or Nanapore in DNA- seq, RNA – seq, break – seq, Guide – seq, or similar.
  • Proven track record in the delivery of robust, testable, well organized and fully documented software packages for Linux platforms. 

If you have experience of any of the following this is advantageous to your application:

  • Command of Biopython, Bioperl, BioJava or Bioconductor.
  • Experience of Open Source data visualisation tools e.g. matplotlib
  • Data mining / cleaning experience with REST API’s for publicly available repositories of datasets such as: RefSeq, Uniport and Ensembl.

In addition to a competitive salary, the company offers an excellent benefits package including: 


  • 25 days Annual Leave plus Bank Holidays
  • Pension with matched employer contribution to 7%
  • Health Insurance
  • Group Life Cover
  • Child Care Voucher Scheme
  • Glasses Vouchers
  • Modern, welcoming working environment


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