Scientist - AAV Vectors - Molecular Biology

Scientist - AAV Vectors - Molecular Biology

Job Title: Scientist - AAV Vectors - Molecular Biology
Contract Type: Permanent
Location: Oxford
Salary: Up to £38,000 plus excellent benefits
Start Date: 2018-10-05
Reference: 15998 JH
Contact Name: James Hume
Contact Email:
Job Published: October 10, 2018 14:55

Job Description

James Hume is recruiting for a Scientist AAV Vectors to join an ambitious company who are at the forefront of synthetic biology and its application to the discovery, development and manufacture of Biologics, Cell & Gene Therapies.  This role is to be part of their AAV Vector group that engineers viral vectors and novel bio – production methodologies working with both academia and industry.  An area that the company wants to continue to expand based on the demand for their expertise.  The purpose of this role is to focus on the generation of molecular constructs for the production of Adeno – associated Virus.

Job Summary:
The Scientist role is to focus on the generation of molecular constructs for the production of AAV vectors, with the responsibility to lead form the bench for both internal R&D and commercial projects.  This role will be supporting the AAV production team as part of the AAV group whose purpose is to to develop solutions for th engineering of viral vectors and novel – bioproduction methodologies. 

This is a senior role in the laboratory where you will be leading projects in the lab with the responsibility for mentoring more junior staff as well as overseeing their work and the delivery of projects.  Going forward you will be an important part as this function grows because this is a growth area for the company, meaning this role has very strong career progression opportunities. 

Desired Skills and Experience:
You will need to be educated to PhD level with preferably some post – doctoral or commercial experience, or with an MSc and commercial experience.  The focus of this role is on AAV vectors meaning you will need to have demonstrable experience of the AAV genetics and gene therapy applications.  With experience of generating complex DNA constructs.  As well as experience of handling adherent cell lines e.g. multiwell plates, hyperflasks / stacks or cell factories. You will need to have experience of using molecular biology techniques including PCR, DNA Sequencing, RT – PCR and ELISA.  With experience of using analytical techniques for the genetics characterisation of Viral particles.

The Company
The company are at the cutting edge of the use of Synthetic Biology to streamline the discovery, development and production of biologics, cell & gene therapies.  Their approach combines cutting edge use of bioinformatics taking advantage of algorithms and other tools that drive forward the rational designs of complex biological systems at the DNA level.  These are then assembled on their automated platform technology which enables them to develop systems for the discovery, engineering, and production of antibodies, viral vectors, packaging & production cell lines for lentivirus and AAV manufacture, CRISPR libraries and CRISPR engineering.  They intend to continue to build in the Viral Therapeutics field based on the capabilities of their technology and the demand for their Lentiviral, AAV and Adenoviral vectors.

They are going through a continued period of expansion due to the demand of their services from industry as well as after entering some major longstanding partnerships.  In addition to this they have other technologies under development after securing funding that will further enhance the portfolio of services they can offer.   They have an excellent culture where staff are all working closely together with the opportunity of rapid promotion as part of their culture and provide the chance to learn new skills.  In addition to the career path they are conscious of the work team members put in and because of this arrange regular events outside of work, away days and other events internally.

In addition to a competitive salary, the company offers an excellent benefits package including: 

  • 25 days Annual Leave plus Bank Holidays
  • Pension with matched employer contribution to 7%
  • Health Insurance
  • Group Life Cover
  • Child Care Voucher Scheme
  • Glasses Vouchers
  • Modern, welcoming working environment