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Research Scientist – Cell Line Development

Research Scientist – Cell Line Development

Job Title: Research Scientist – Cell Line Development
Contract Type: Permanent
Location: London
Salary: Excellent Salary D.o.E. plus bonus & excellent benefits
Start Date: ASAP
Reference: 16192 JH
Contact Name: James Hume
Contact Email: james.hume@nextphaserecruitment.com
Job Published: April 08, 2019 10:29

Job Description

A fast developing clinical stage Biotech whose technology is based on programmed  T – cells and located in west London are seeking Research Scientists with Cell Line Development expertise to join their Process Development Group. 

The purpose of the role is to support the development of manufacture of viral vectors by developing cell lines for viral vectors as well as the design and cloning of vectors such as lentiviral and retroviral.  This includes the development of both adherent and suspended cell lines using mammalian primary cells and related culture methods.  You will also be involved in screening activities to identify the best conditions and cell lines for the production of vectors.  As this is a more senior role in the team you will help develop the best processes and strategies for the manufacture of vectors working with more senior staff members.  With the responsibility for the mentoring of junior members to support their career development and ensure work is of the right quality. They use a wide range of techniques in their laboratories including flow cytometry, ELISA and qPCR.

They are a clinical stage Biotech who have developed CAR – T cell therapies for the treatment of cancers by developing programmed cells using their modular technology to engineer precisely targeted, controlled and active therapies.  To complement their therapies at the clinical stage they have a strong pipeline behind these including those due to reach trials soon.  The organisation has existed for 4 years and is very well funded, with a clear strategy and expansion plan for the next 3 years to bring their current therapies to commercial launch and beyond

Desired Skills and Experience:

For this opportunity, you will need to be ideally educated to PhD level in a relevant scientific discipline with postdoctoral experience in academia or industry.  However, and MSc with relevant experience is just as valuable.  You will need to have experience of cell based techniques (transfection and transduction) and the cell culture of both adherent and suspended mammalian cell lines.   You will need to have experience of techniques including flow cytometry, ELISA, qPCR, and preferably the extraction and purification of nucleic acids.  If you have production and purification experience with multiple vector platforms then this is advantageous to your application.