Research Scientist – Upstream Process Development

Research Scientist – Upstream Process Development

Job Title: Research Scientist – Upstream Process Development
Contract Type: Permanent
Location: London
Salary: Excellent Salary D.o.E. plus bonus & excellent benefits
Start Date: ASAP
Reference: 16193a JH
Contact Name: James Hume
Contact Email:
Job Published: April 09, 2019 10:25

Job Description

A fast-developing clinical stage Biotech whose technology is based on programmed T – cells and located in west London are seeking Research Scientists with viral vector Upstream Process Development experience to join their R&D Group.

The purpose of the role is to develop manufacturing processes for viral vectors such as lentiviral and retroviral with a focus on the upstream process development of these.  You will be performing scale up operations using cell based and automated processes covering the development of new and the optimisation of existing methods.  This includes the characterisation and optimisation of manufacturing processes and analytical assays.  As a more senior member of the team you will also be involved in the tech transfer of methods to their manufacturing facility in Stevenage.  Supervise and train more junior members of staff to ensure the quality of their work and the development of their careers.  Plus additional activities such as the investigation of new equipment and technology for vector manufacture and the characterisation of processes. 

They are a clinical stage Biotech who have developed CAR – T cell therapies for the treatment of cancers by developing programmed cells using their modular technology to engineer precisely targeted, controlled and active therapies.  To complement their therapies at the clinical stage they have a strong pipeline behind these including those due to reach trials soon.  The organisation has existed for 4 years and is very well funded, with a clear strategy and expansion plan for the next 3 years to bring their current therapies to commercial launch and beyond

Desired Skills and Experience:

For this opportunity, you will need to be familiar with a range of biopharmaceutical techniques such as cell culture, cell based techniques and vector production.  You will need to have experience in the production and purification of viral vectors or related products such as proteins.  Ideally you will be educated to PhD level with experience in either academic or industry, or an MSc with experience in the same areas.  You will need to have experience in the quantification and characterisation of products.  If you have direct viral vector experience then this is advantageous to your application but not essential.