Senior Scientist - Cell Engineering

Senior Scientist - Cell Engineering

Job Title: Senior Scientist - Cell Engineering
Contract Type: Permanent
Location: Oxford
Salary: Competitive
Start Date: 2020-01-29
Reference: V-46056
Contact Name: James Hume
Contact Email:
Job Published: January 29, 2020 11:24

Job Description

A biotech who are pioneering the application of CRISPR led cell engineering, automation and bioinformatics to redefine what is possible for mammalian cell engineering are recruiting for a Senior Scientist within the Cell Line Development team to take the lead and apply your scientific expertise in the development of lines for the manufacture of therapeutic proteins.


As a company they are a specialised contract organisation who are providing platforms and solutions that accelerate the discovery, development and manufacture of cell & gene therapies.  Their technologies enable them to carry out targeted cell engineering using automation and informatic driven methods to advance the delivery of new therapeutics.  They have a strong Culture that is very inclusive with regular activities arranged outside of work that are planned or ad hoc with ad hoc rewards give and away days.   Added to this their career progression is strong with regular promotions occurring throughout the company due to their training programmes, exposure gained and importantly opportunities created to move to more senior or technical roles depending on the direction you want your career to take.



For example they have, and continue to, develop platforms enable them to develop scalable methods for the production of viral vectors – AAV, Lentivirus and Adenovirus.  With sector leading expertise in the use and application of CRISPR such as the design and construction libraries and screening processes.  As well as high throughput automated CRISPR gene editing of mammalian cell lines for a range of applications.  They have developed a novel antibody display technology that enables them to  target challenging membranes through mammalian display, and optimised expression systems to accelerate discovery against intractable targets.  Additionally, they have an automated expression platform for rapid small scale antibody production and characterisation.


As a Senior Scientist in their Cell Line Development team will take the lead on projects that are both external collaborative R&D projects and internal platform development work to opitmise existing and create new platforms.  Working with the Group Leader to design experimental programmes which you will then execute in the laboratories working with more junior colleagues. 


The projects will be to develop CHO – based cell lines for the manufacture of therapeutic proteins, developing methodologies for the optimization of growth conditions, genetic manipulation of cell lines using their proprietary technologies and product quality attributes.  With experience in using analytical techniques for the characterisation of lines such as PCR and Flow Cytometry. Working closely with colleagues in other groups such as the protein engineering viral vector expression and process development groups.  This role oversees projects to ensure they are delivered requiring a mix of hands on work in laboratories to develop methods and to support colleagues undertaking the bench work.  To complement to collaborator interaction and project based work.



Desired Skills and Experience:


They are preferably looking for a PhD qualified scientist with experience in the development of mammalian cell lines for protein manufacture through the genetic manipulation of cells lines.  With expertise in the optimization of cell growth conditions, cell culture, working with suspended cell lines and generating stable, clonal lines.  With experience in the use of analytical techniques to characterize cellines using flow cytometry, PCR and other assays such as ELISA.