Senior Scientist - Process Development Downstream

Senior Scientist - Process Development Downstream

Job Title: Senior Scientist - Process Development Downstream
Contract Type: Permanent
Location: Oxford
Salary: Competitive
Start Date: 2020-02-26 00:00:00
Reference: V-46103
Contact Name: James Hume
Contact Email:
Job Published: March 15, 2020 15:08

Job Description

An Oxford based Biotech are recruiting for a Senior Scientist to join their Process Development team to lead Downstream activities for novel viral vectors and therapeutic proteins.  This role is part of the wider Process Development team that includes upstream and analytics to complement downstream activities.  

Their Process Development Group has been earmarked for development both in terms of team size and technical capabilities.  With the Senior Scientist being integral to this by acting as the technical lead for both external commercial projects and internal R&D projects.  With the purpose to develop downstream process development capabilities for both viral vectors and therapeutic proteins.   Working with the Group Leader expand the downstream capacity to enhance their offerings whilst delivering commercial projects and responsible for mentoring 2 junior members of the team.

As the Senior Scientist you will lead projects for the identification and implementation of scalable processes for primary recovery and product purification.  As a Group they work closely with the Viral Vector and Cell Line Development teams, with a focus on Lentiviral AAV, and Adenoviral vectors.  There are a number of ongoing  programmes both internal R&D and external commercial projects that you will be involved in.  

Desired Skills and Experience:
They are looking for a PhD qualified scientist with experience of developing and implementing downstream processes for mammalian systems for viral vectors.  You will need to have experience of techniques such as TFF, ultracentrifugation and AKTA based chromatography, for examples Affinity, IEX and SEC.  If you have experience of working in a GMP regulated environment this is advantageous to your application but not essential.  If you have experience of statistical approaches and / or QbD principles then this is also advantageous to your application. 

Company overview:
As a company they are a specialised contract organisation who are providing platforms and solutions that accelerate the discovery, development and manufacture of cell & gene therapies.  Their technologies enable them to carry out targeted cell engineering using automation and informatic driven methods to advance the delivery of new therapeutics.  

For example they have, and continue to, develop platforms enable them to develop scalable methods for the production of viral vectors – AAV, Lentivirus and Adenovirus.  With sector leading expertise in the use and application of CRISPR such as the design and construction libraries and screening processes.  As well as high throughput automated CRISPR gene editing of mammalian cell lines for a range of applications.  They have developed a novel antibody display technology that enables them to  target challenging membranes through mammalian display, and optimised expression systems to accelerate discovery against intractable targets.  Additionally they have an automated expression platform for rapid small scale antibody production and characterisation.