The role of Senior Scientist is at the core R&D site for a company that is driven to develop the best AAV based Gene Therapies globally and now have therapies in the clinic that prove this. Their focus is on genetic disorders. such as those that affect the central nervous system, muscles, and heart tissues. Please note there are multiple positions available.
Their Edinburgh site is the R&D Engine of the company developing new platform technologies or enhancing existing platforms as they progress to clinical trials. With technology that focuses on wild type AAV vectors allied with sector leading gene expression tools, gene dosing and high yield AAV manufacturing capabilities.
The Edinburgh site is seen as the centre of excellence for the engineering of cell lines for use in production of AAV Vectors. Working with machine learning and bioinformatics experts to develop stable cell lines to transfer to the manufacturing team. As a Senior Scientist you will be designing and driving experimental programmes in the laboratories and mentoring more junior team members. With the purpose to give you the exposure to move to a more senior role as your career develops with the company.
They are engineering cell lines using techniques such as CRISPR, Gibson Assembly and Golden Gate for example. As a Scientist you will be executing experimental programmes in the laboratories to develop cell lines using your science to contribute to their design.
Using your analytical capabilities the development of assays for the characterisation of cell lines. Using your abilities to solve challenges presented when developing lines for the manufacture of viral vectors.
For this opportunity you will need to have a relevant degree or high qualification with experience of working in commercial environments. With experience of engineering mammalian or human cell lines e.g CHO or HEK.
You will need to have experience of using techniques such as CRISPR or Gibson Assembly or Golden Gate or Site Directed Mutagenesis for example to generate stable cell lines ready for manufacture. As well as analytical techniques that includes flow cytometry and FACS.