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  • Location: Cambridge
  • Salary: Competitive
  • Job Type:Permanent

Posted about 2 months ago

  • Sector: Translational Science
  • Contact: James Hume
  • Contact Email:
  • Contact Phone: 01403 216216
  • Start Date: 2021-03-01
  • Job Ref: V-46658

This is a trulyrareopportunity to take on an opportunity where your responsibility is to push boundaries and apply your blue-sky thinking approach to synthetic biology.  This Cambridge based start who are renowned for their approach and growing impact on the sector are seeking a Senior Scientist who fits this mould to join the Synthetic Biology team. As a Group they are continually seeking synthetic approaches for cellular programming for application in cell therapies and generation of iPSC’s.

The Role of Senior Scientist:

As a Senior Scientist you will be a leader within in this team of both people and science.  Mentoring more junior members for the team and directing their day-to-day work to ensure projects are delivered on time.  With the science focus on applying a blue-sky thinking to what is possible via cell programming.  This team is a focal point for the company with influence across a range of groups.

Responsibilities includes:

  • Design, develop and implement synthetic biology R&D programmes to keep the company at the forefront of this sector.

  • Develop novel molecular engineering and gene engineering platforms – including automated systems.

  • Work in collaboration with a range of internal groups to develop customised solutions to achieve the company’s scientific goals through the application of the latest molecular & synthetic techniques.

  • Operate in close partnership with 3rd parties, driving these collaborations forwards.

  • Lead more junior members of the team as a scientific mentor and direct their day-to-day operations.

Your Expertise:

For this opportunity you will need to have:

  • A relevant PhD or significant experience in the field

  • DNA Cloning expertise including – form example Gibson Assembly or Golden Gate

  • DNA manipulation techniques for delivery and site-specific integration assemblies into genomes

  • Experience of working with mammalian / bacteria / yeast.

  • Expertise in the use of molecular biology techniques and assays – PCR, ddPCR, sequencing, NGS, gene synthesis

If you have any of the following this is advantageous to your application:

  • Hight throughput or automated cloning systems

  • Genome or gene editing – e.g. CRIPSR

The company:

They are based in Cambridge and their step change technology that is a combination of stem cell biology and synthetic biology.  The purpose of this is to accelerate the discovery, development, and manufacture of cell therapies through the control of synthetic biology circuits.

Their aim is to build a scalable model that enables the production of cells that are actually affected by the targeted disease and accelerate the development of cures.  Their focus is currently on human induced Neurological and Skeletal stem cells.

They received significant funding to complement their own plans which has led to a rapid expansion as they meet their current aims and work towards the development of new ideas.