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  • Location: Cheshire
  • Salary: A highly competitive package which is based accordingly with experience and skills
  • Job Type:Permanent

Posted about 1 year ago

Do You Have Experience Working in A Drug Discovery Environment as a Computational Chemist?

I am looking for a Principal Computational Chemist for a leading CRO which is highly praised for its outstanding drug discovery services. In this role, you will have the opportunity to work on integrated drug discovery projects with some of the most high-profile global biotech and pharma companies in the industry. The company is at the forefront of applying new software and techniques to solve challenging problems for highly established clients, and you will be a part of this exciting and expanding group.

The role is on a permanent basis in Alderley Park, offering a generous package plus attractive benefits including hybrid working and sponsorship / relocation assistance if necessary. The company's history has been very successful, having discovered over 30 compounds for their highly established customers, with over 20 progressing to clinical trials. The company has experienced exponential growth over the last 5 years which has been pioneered by their continued breakthroughs within the drug discovery industry.

As a Principal Computational Chemist, your role will include:
  • Collaborate with customers to understand their requirements and develop compelling project proposals
  • Lead the execution of computational work to an exceptional standard being at the forefront of scientific research, driving projects with the latest scientific software and cloud-based technology, ultimately solving complex challenges for world renowned clients
  • Manage, mentor, and oversee a team of computational chemists
  • Contribute to the promotion and dissemination of scientific research in the area of computational chemistry
  • Participate in the leadership team to influence the strategic direction of the group
  • Take an active role in the training and further development of the computational chemistry team
  • Utilise new modalities such as protacs, molecular glues, macrocycles and other beyond rule of 5 compounds
  • Apply new and emerging free energy methods to calculate binding energies

The company is based in Alderley Park and provides hybrid working with 3 days on site with a fantastic working environment. The role will include significant involvement in leading client facing projects and will apply your computational chemistry skills to the highest calibre, to produce cutting edge scientific research that helps clients produce innovative medicines that aim to improve the welfare of people's lives across the globe.

Skills and Experience Required:
  • Must hold a PhD in computational chemistry or a related field
  • A minimum of 5 years of industry experience is required
  • Demonstrated experience in pitching work to both internal and external customers
  • Proficient in creating persuasive content for quotes and reports
  • Ability to apply computational chemistry at various stages of the drug discovery pipeline
  • Prior experience working in a CROs or large pharmaceutical companies is preferred, but not essential
  • Experience in line management is preferred, but leadership potential is highly valued
  • Strong verbal and written communication skills
  • Experience in AI/ML applied to drug discovery projects
  • Passion for new technologies and the confidence to apply them in projects

This position offers a highly competitive package which scales accordingly with experience and skills.


If you have any questions about the role or would like to recommend someone who would be suitable for this position, please feel free to send an email to