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  • Location: London
  • Salary: £40000 - £45000 per annum, Benefits: bonus, pension, life insurance, health insurance, 25 days holiday.
  • Job Type:Permanent

Posted 4 days ago

  • Sector: Translational Science
  • Contact: James Hume
  • Contact Email: james.hume@nextphaserecruitment.com
  • Contact Phone: 01403 216216
  • Start Date: 2022-01-14
  • Job Ref: V-47106-1a
 A clinical stage T – Cell Therapy company who are pioneers in the sector with therapies advancing through clinical trials based on their proprietary technology for the reprogramming of T Cells.  They use this technology to engineer precisely targeted, specific and active T cell therapies that are capable of identifying cancels cells to then eliminate these.  They have an expanding pipeline of therapies with some at differing stages of clinical trials and others under development.  Added to this they are now constructing their own manufacturing facility to meet the changing and increasing needs of the company.

 
Role Overview:

They are continuing to develop and expand their Process Development capabilities as their pipeline progresses towards GMP manufacture.  They are seeking a Senior Scientist to join their Cell Line Development team with the focus on creating highly productive and robust cell lines.  As a Senior Scientist you will be a technical lead and viewed as a subject matter expert of cell line development.  With the responsibility for leading a small team in their day to day operations.  Importantly you will have input into the design of experimental programmes, influence the direction of projects and research.

Responsibilities includes:

  • Be a key part in the development of projects for cell line development.
  • Provide scientific guidance to junior team members and wider Process Development Group.
  • Develop cell lines for the manufacture of Viral Vectors e.g. HEK293
  • Apply cloning techniques such as Golden Gate, Gibson Assembly or others.
  • Apply screening of cell lines and development of techniques.
  • Use analytical methods such as flow cytometry / FACS.
  • Work collaboratively with other team members within the Process Development Group.
 

Desired Skills and Experience:

  • PhD or MSc in relevant scientific field
  • Relevant experience of cell line development e.g. HEK293 or CHO cells
  • Experience of constructing and evaluating recombinant mammalian cell lines for recombinant molecule production.  Preferably for Lentiviral / Retroviral vectors but this is not essential.
  • Practical knowledge of mammalian expression systems for the production of recombinant molecules.
  • Experience of flow cytometry and its application for cell line development.
  • Experience with advanced molecular biology techniques e.g. NGS / DNA sequencing
  • Experience in the mentorship / leadership of junior team members.
 

The Company

The company are a pioneering and ambitious Biopharmaceutical company who have developed next-generation, programmed T-cell therapies to treat haematological cancers and solid tumours. Scientifically, the company has extremely exciting technologies, using a broad suite of proprietary and modular T-cell programming to engineer precisely targeted, controlled and highly active T cells. Commercially, they have a pipeline of product candidates in development (for the treatment of haematological malignancies and solid tumours) and is increasing its GMP production capacity. Based in a state-of-the-art facility in Stevenage, Hertfordshire, you will join a team that is doing something genuinely meaningful.