Mid/Senior Computational Drug Discovery Scientist Bolton

Mid/Senior Computational Drug Discovery Scientist

Computational Drug Discovery Scientists use modelling and simulation to accelerate early-stage drug discovery. They design and optimize small molecules through computer-aided drug design (CADD) and structure-based modelling.

Core duties:

• Running molecular docking, dynamics, and pharmacophore modelling – Using software like Schrodinger, MOE, or OpenEye.

• Collaborating with medicinal chemistry and biology teams – Informing compound selection and SAR analysis.

• Designing virtual screening workflows – Prioritising libraries and filtering based on predicted properties (e.g., ADMET).

• Building QSAR and ML models – To predict compound activity and guide lead optimization.

• Contributing to publications and intellectual property – Supporting innovation across internal pipelines or collaborations.

Candidates typically have a PhD in computational chemistry, structural biology, or cheminformatics, with strong coding and visualization skills.​

Bolton

Bolton is a town in north-west England approximately 10 miles from Manchester.   During the Industrial Revolution Bolton grew from a small cotton and wool weaving  town to a large textile manufacturing centre during the Industrial Revolution with over 200 cotton mills at its peak.  In recent times heavy industry has largely been replaced by service industries such as data processing, call centres, electronics, life sciences and IT.  Bolton has a number of museums, theatres and other attractions including brewery tours, heritage trails, shops, local produce markets, a good range of shops.  The West Pennine Moors are within easy reach for walking and cycling.

Famous people born in Bolton:  Amir Kahn , boxer and Peter Kaye, comedian