Mid/Senior Computational Drug Discovery Scientist South West

Mid/Senior Computational Drug Discovery Scientist

Computational Drug Discovery Scientists use modelling and simulation to accelerate early-stage drug discovery. They design and optimize small molecules through computer-aided drug design (CADD) and structure-based modelling.

Core duties:

• Running molecular docking, dynamics, and pharmacophore modelling – Using software like Schrodinger, MOE, or OpenEye.

• Collaborating with medicinal chemistry and biology teams – Informing compound selection and SAR analysis.

• Designing virtual screening workflows – Prioritising libraries and filtering based on predicted properties (e.g., ADMET).

• Building QSAR and ML models – To predict compound activity and guide lead optimization.

• Contributing to publications and intellectual property – Supporting innovation across internal pipelines or collaborations.

Candidates typically have a PhD in computational chemistry, structural biology, or cheminformatics, with strong coding and visualization skills.​

The South West

The South West region is one of the nine official regions of England.  It consists of Gloucestershire, Bristol, Wiltshire, Somerset, Dorset, Devon and Cornwall, including the Isles of Scilly. Major towns and cities in the region include Bristol, Plymouth, Swindon, Gloucester, Cheltenham, Exeter, Bath, Truro and Bournemouth.  Agriculture and Tourism are the major employers in the west of the region which is less prosperous in general than the east of the region, due in part to the better transport links to London enjoyed by the latter.  In Bristol, Swindon and the M4 corridor the economy centres on aeronautics, defence, telecommunications, electronics, technology and IT.   The region is famous for being home to Stonehenge, Glastonbury, the Eden Project and a wealth of stunning beaches and countryside.

Famous people born in the south West:  Ben Ainslie, multiple Olympic sailing gold medallist and Agatha Christie, novelist/crime writer