Senior Scientist II, PD Vector – Upstream Barnsley

Senior Scientist II, PD Vector – Upstream

Senior Scientists in Upstream Process Development for Vector Production lead process design and optimisation for viral vector manufacturing, crucial for gene therapies and vaccines.

Key tasks include:

• Designing transfection or infection workflows – Using HEK293, Sf9/Baculovirus, or AAV platforms.

• Scaling up processes from bench to bioreactor – Optimising parameters such as MOI, media composition, and harvest timing.

• Writing process protocols and technical reports – Supporting internal reviews and regulatory documentation.

• Troubleshooting production challenges – Investigating yield, impurity, or cell viability issues.

• Collaborating with downstream and analytical teams – To ensure process compatibility and consistent product quality.

This role combines deep technical knowledge with problem-solving and cross-functional collaboration in GMP development settings.​

Barnsley

Barnsley is located in South Yorkshire in the north of England halfway between Leeds and Sheffield and within easy reach of other large towns including Doncaster, Huddersfield and Wakefield.   Originally mentioned in the Domesday Book, Barnsley grew into an industrial town centred on coal mining and glassmaking.   Clinical research, healthcare, manufacturing and technology are among the many business areas currently providing employment in Barnsley.  Barnsley is a foodie heaven with one of the best markets in South Yorkshire complemented by farm shops selling excellent local produce, country pubs, tea rooms and restaurants.  Rolling countryside, including the Peak District,  is easily accessible from Barnsley and is part of the Tour de Yorkshire route. 

Famous people born in Barnsley:  Dickie Bird (cricket umpire), Michael Parkinson (TV chat show host)