Senior Scientist II, PD Vector – Upstream Bolton

Senior Scientist II, PD Vector – Upstream

Senior Scientists in Upstream Process Development for Vector Production lead process design and optimisation for viral vector manufacturing, crucial for gene therapies and vaccines.

Key tasks include:

• Designing transfection or infection workflows – Using HEK293, Sf9/Baculovirus, or AAV platforms.

• Scaling up processes from bench to bioreactor – Optimising parameters such as MOI, media composition, and harvest timing.

• Writing process protocols and technical reports – Supporting internal reviews and regulatory documentation.

• Troubleshooting production challenges – Investigating yield, impurity, or cell viability issues.

• Collaborating with downstream and analytical teams – To ensure process compatibility and consistent product quality.

This role combines deep technical knowledge with problem-solving and cross-functional collaboration in GMP development settings.​

Bolton

Bolton is a town in north-west England approximately 10 miles from Manchester.   During the Industrial Revolution Bolton grew from a small cotton and wool weaving  town to a large textile manufacturing centre during the Industrial Revolution with over 200 cotton mills at its peak.  In recent times heavy industry has largely been replaced by service industries such as data processing, call centres, electronics, life sciences and IT.  Bolton has a number of museums, theatres and other attractions including brewery tours, heritage trails, shops, local produce markets, a good range of shops.  The West Pennine Moors are within easy reach for walking and cycling.

Famous people born in Bolton:  Amir Kahn , boxer and Peter Kaye, comedian