Senior Scientist II, PD Vector – Upstream South West

Senior Scientist II, PD Vector – Upstream

Senior Scientists in Upstream Process Development for Vector Production lead process design and optimisation for viral vector manufacturing, crucial for gene therapies and vaccines.

Key tasks include:

• Designing transfection or infection workflows – Using HEK293, Sf9/Baculovirus, or AAV platforms.

• Scaling up processes from bench to bioreactor – Optimising parameters such as MOI, media composition, and harvest timing.

• Writing process protocols and technical reports – Supporting internal reviews and regulatory documentation.

• Troubleshooting production challenges – Investigating yield, impurity, or cell viability issues.

• Collaborating with downstream and analytical teams – To ensure process compatibility and consistent product quality.

This role combines deep technical knowledge with problem-solving and cross-functional collaboration in GMP development settings.​

The South West

The South West region is one of the nine official regions of England.  It consists of Gloucestershire, Bristol, Wiltshire, Somerset, Dorset, Devon and Cornwall, including the Isles of Scilly. Major towns and cities in the region include Bristol, Plymouth, Swindon, Gloucester, Cheltenham, Exeter, Bath, Truro and Bournemouth.  Agriculture and Tourism are the major employers in the west of the region which is less prosperous in general than the east of the region, due in part to the better transport links to London enjoyed by the latter.  In Bristol, Swindon and the M4 corridor the economy centres on aeronautics, defence, telecommunications, electronics, technology and IT.   The region is famous for being home to Stonehenge, Glastonbury, the Eden Project and a wealth of stunning beaches and countryside.

Famous people born in the south West:  Ben Ainslie, multiple Olympic sailing gold medallist and Agatha Christie, novelist/crime writer