Bioprocess Scientist – Viral Systems

Bioprocess Scientist – Viral Systems

Job Title: Bioprocess Scientist – Viral Systems
Contract Type: Permanent
Location: London
Salary: Up to £38,000 plus excellent benefits
Start Date: 2017-04-13
Reference: 15362 JH
Contact Name: James Hume
Contact Email:
Job Published: April 13, 2017 17:26

Job Description

  • Bioprocess Scientist –Viral Systems
  • Location: Central London
  • Salary: Up to £38,000 plus excellent benefits including bonus, 15% pension, private medical cover, life assurance plus others
  • Experience of Upstream or Downstream Bioprocessing of Biologics is Essential
  • Specific Experience of the Bioprocessing of Viral Vectors Systems is Advantageous to your Application.
  • GMP Experience is also Advantageous to Your Application.

James Hume is recruiting for a Bioprocess Scientist to join a centre of excellence for the development of cell and gene therapies based in Central London.  The company’s aim is to work with their collaborators from both academia and industry to take their novel technologies from concept through the commercialisation process to launch.  They have the expertise to bridge the gap between scientific research and clinical trials, managing this process to ultimately result in the therapy being launched to the market.  To further develop their research they need to recruit a Bioprocess Scientist to support the development of their viral vector industrialisation projects. 

The Company
The company have established a centre of excellence at their Central London laboratories to support the development of cell and gene therapies through the commercialisation process. They collaborate with academic and industrial partners, who are developing novel therapies, to take these from the concept stage to the market by using cutting edge methodologies to achieve this.  In addition to the laboratory support they are able manage the clinical trial process across all phases to product launch.  They provide process development, manufacturing, analytical development, clinical, regulatory, quality, health economics and market access expertise to achieve this.  So far they have successfully taken therapies through to stage II clinical trials, and were in fact the first to do so in the UK.  They are now putting in place the facilities to support large phase III trials and the increasing volume of development projects.  With the construction of a new facility that is to be based in Stevenage opening early next year.  Regenerative medicine is one of the Government’s “eight great technologies” and the company aims to make the UK the logical choice for UK based and international partners to develop and commercialise their advanced therapies.       

The Opportunity
This role is within the viral vector industrialisation group where you will use sate of the art tools to identify the process and analytical developments that will make the largest impact on the cost of goods, quality and yield of the manufactured product.  You will support the upstream or downstream bioprocessing, depending on your skill set, of the vectors working as part of a wider team.  You will be working with Senior Scientists to help design the process development activities for the viral vector projects.  Then working autonomously to conduct the experiments using QBD principles and industrial bioprocessing techniques such as fixed bed reactors, STR’s, downstream chromatography, and analytical techniques.

As well as the laboratory work you will analyse raw data to present these results to project teams as well as external collaborators.  You will also work with the Tech Transfer team with the transfer of methods by writing documents such as SOP’s to support this process.  You will also establish links with academic and industrial partners to provide solutions for viral vector cell line development (upstream or downstream).  The purpose of this is to gain valuable experience to help build your experience enable you to progress your career in this growing company.   

Desired Skills and Experience
You will need to have experience of the upstream or downstream bioprocessing of biologics, if you have experience of working with viral vectors then this is advantageous to your application.  You will need to have cell culture experience of human and / or mammalian cell lines using bioreactors, preferably a variety of these.  If you have experience of working in a GMP environment then this is also advantageous.  In addition you will need to be educated to at least degree or equivalent level in a relevant and a higher level qualification (MSc or PhD) is advantageous to your application.  

Virus, viral, viral vector, bioprocessing, upstream, downstream, GMP, in vivo, ex vivo, gene therapy, cell therapy, vector, analytical development, scale up, bioprocess, biologics, bacteria, mammalian, human, cell culture, industrialisation, commercialisation, engineering, bioreactor, chromatography, filtration, separation, purification, assay, characterisation, in process, control, AAV, lentiviral, retroviral

This is a permanent role