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  • Location: Boston
  • Salary: Competitive salary with great benefits package
  • Job Type:Permanent

Posted 10 months ago

My client is at the forefront of revolutionizing drug discovery through the power of Artificial Intelligence (AI) and computational chemistry. We are looking for a dynamic and driven Computational Chemist to join our innovative team and contribute to our mission of redefining the way we discover life-saving drugs. As a Scientist in Computational Chemistry, you will have the unique opportunity to work closely with experts in various fields, including machine learning, medicinal chemistry, and software engineering, to develop novel therapeutic solutions that address unmet medical needs.
Company Summary:
My client is not your typical pharmaceutical company. They are a blend of cutting-edge computational technologies with life sciences to create safer and more effective therapeutics that defy traditional drug discovery methods. Their team comprises curious, multidisciplinary professionals who are passionate about making a meaningful impact in Life Sciences.
As a Scientist in Computational Chemistry, you will:
  • Collaborate closely with project teams to contribute scientifically and strategically to the development of clinical candidates.
  • Develop and implement computational strategies to identify and optimize lead-like molecules targeting various cellular pathways and mechanisms.
  • Work in tandem with medicinal chemists and biologists to design innovative small molecules and enhance their efficacy, safety, and drug-like properties through computational techniques.
  • Pioneer new computational approaches to explore unique chemistry spaces.
  • Conduct research to advance computational chemistry tools and methods aligned with the company’s mission.
  • Effectively communicate computational results and analyses to project team members and stakeholders.
  • Collaborate closely with the MedChem group to provide proactive inputs related to hit finding and hit-to-lead optimization.
Required Qualifications:
  • A Master's or Ph.D. degree in Chemistry, Biochemistry, Computational Chemistry, Chemical Engineering, or a related field.
  • A minimum of 2 years of industry experience in small molecule drug discovery.
  • A strong passion for drug discovery and a solid grasp of medicinal chemistry concepts.
  • Proficiency in implementing computational strategies across all stages of drug discovery.
  • Practical experience with computational chemistry software (e.g., Schrodinger, ICM Molsoft, OpenEye, CCG, etc.).
  • Expertise in one or more of the following: docking studies, virtual screening, druggability analysis, structure-based design, free energy perturbation, and molecular dynamics simulation.
  • Exceptional communication and interpersonal skills to thrive in a dynamic, multidisciplinary team.
Preferred Qualifications:
  • Hands-on experience with advanced MD/FEP simulation methods for protein-small molecule complexes.
  • Basic programming skills (Python, Jupyter notebook, bash).
  • A demonstrated ability to innovate within strong multidisciplinary project teams and collaborate effectively with internal and external partners.