- Job Title: Group Leader – Cell Line Development
- Salary: D.o.E. plus benefits
- Location: Oxford
- Excellent Opportunity to Join a Growing Company at the Forefront of the Biotech Revolution who have Great Potential
- An Influential Role Leading a Team of Multi Disciplinary Scientists Developing Processes for the Engineering of Cell Lines for the Production of Viral Vectors and Therapeutic Proteins.
This is a truly exciting opportunity to join a fast developing biotech who are pioneers in the use of synthetic biology and its application to transform the discovery, development and manufacture of biologics, cell & gene therapies. Based in state-of-the-art laboratories near Oxford they are at the cutting edge of research in this field, which has huge potential to deliver solutions for the production of complex, high value products. They need to recruit a Group Leader who can lead a team to deliver research projects in partnership with commercial organisations, alongside internal platform development projects that are crucial to the continued growth of the company.
The Company
The company are at the cutting edge of the exciting field of synthetic biology after developing their unique platform which enables them to offer solutions to the discovery, development and manufacture of biologics, cell & gene therapies. They currently offer a range of custom and platform services, specialising in DNA design, optimisation of protein and viral expression systems, and cell line development technologies.
A strong focus is placed on R&D activities and further developing platform technologies, as supported by the recent receipt of multiple grants awards from Innovate UK. Which will enable them to realise their potential and have a positive impact on the cell and gene therapy sectors.
The Opportunity:
The Group Leader is an influential role leading a team of multi – disciplinary scientists developing processes in mammalian cells for the production of therapeutic proteins and viral vectors. You will be using your technical expertise of CRISPR and / or other gene editing tools to drive projects forwards overseeing the work of you team to develop processes for the manufacture of viral vectors such as lentivirus, AAV and retrovirus. Plus therapeutic proteins depending on the requirements of the projects.
As the Group Leader you will be line managing a team of c8 scientists working on both internal and external research projects. With the responsibility for their line management, performance and training & development. Acting as their mentor to help develop their own skills and support their career progression. The projects you will be leading cover both internal platform development projects and external client projects. Working in close collaboration with other departments such as Molecular Biology and Bioinformatics to deliver results.
They are seeking a creative scientist who can bring on board new technologies, develop new methods using their cutting edge technologies, keep up to date with sector developments to ensure they stay at the forefront of research into this exciting and fast developing sector.
Desired Skills and Experience:
They are looking for a PhD, or equivalent, qualified scientist in a relevant discipline with experience of the generation of cell lines for bio production. You will need to have experience of working with gene editing tools such as CRIPSR or others. Alongside this you will also need to have experience of managing teams both directly and in a matrix environment. As well as experience of overseeing the quality of work completed so that it meets regulatory requirements and company standards. With the ability to engage with external clients to provide updates, reports and scientific expertise.
Keywords
Virus, viral, viral vector, bioprocessing, upstream, downstream, GMP, in vivo, ex vivo, gene therapy, cell therapy, vector, analytical development, scale up, bioprocess, biologics, bacteria, mammalian, human, primary, cell culture, industrialisation, commercialisation, engineering, bioreactor, chromatography, filtration, separation, purification, assay, characterisation, in process, control, biochemistry, molecular biology, cell line, mammalian, cell culture, synthetic biology, flow cytometry, recombinant protein, antibody, retrovirus, lentivirus, protein expression, robot, automation, bioreactor, manage, line management, matrix, protein, therapeutic protein.