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  • Location: Oxford
  • Salary: Competitive salary and benefits package
  • Job Type:Permanent

Posted over 1 year ago

  • Sector: Scientific Development
  • Contact: Aaron Stone
  • Contact Email:
  • Contact Phone: 01403 216216
  • Start Date: 2023-03-13
  • Job Ref: V-47720
Molecular Virology Biologist required for a growing Biopharma company based in Oxford who discover and develop immunotherapeutics products and vaccines for the treatment and prevention of infectious diseases and cancer. This Molecular Virology Biologist will have experience in viruses such as (but not limited to) adenovirus, adeno-associated virus, lentivirus, herpesvirus, with a strong molecular biology background as well as cell/virus culture experience. This role will be integral in designing, interpreting and conducting laboratory studies in the context of discovery and preclinical research phases of novel therapeutic products.
On offer for the suitable individual is a competitive salary and benefits package which includes a bonus and stock options. As well as flexible working hours and a great culture with benefits such as a games room and an open door policy. This role will be on site 5 days a week.
The Molecular Virology Biologist is going to cover the following responsibilities:
  • Give input to the strategy and develop and conduct laboratory work involved in the design, construction, growth, and evaluation of viral vector vaccine candidates.
  • Keep up to date on the field of immunotherapeutics, and review and suggest new approaches, alternative laboratory methods, or new studies to improve the outcome of a given objective.
  • Perform quality control assays on research-grade viral vectored vaccine preparations (physical titer, infectious titer, sequence verification, transgene expression)
  • Maintain and evaluate both mammalian and bacterial cell cultures for growth conditions, DNA purification and viral vector production, and interpret and present the data in a concise and orderly fashion.
  • Assist in studies to optimise the ability to manufacture viral-vectored vaccines, such as evaluation of alternative transfection systems, host or vector gene deletions or insertions, viral culture yield, systems for viral growth, etc.
  • Evaluate and perform analytic assays to determine the quality, yield, stability, etc. of specific candidates or of specific manufacturing process conditions as required.
  • Assist in ordering supplies, making reagents and maintaining the laboratory in order to conduct necessary experiments.
  • Work under GRP (good research practice) conditions, with the appropriate requisite training and documentation
  • Participate in the development and conduct of laboratory meetings, and give presentations inside and outside the company as required.
  • Attend at least one relevant scientific meeting/course per year to continue educational advancement.
The ideal background for this individual will include:
  • Master’s degree plus 4 years of laboratory experience, or a recent PhD, in virology/molecular biology
  • Relevant work experience, with demonstrated experience in laboratory bench work with molecular biology and cell and virus culture systems
  • 3Proficiency in designing experiments and conducting research using a variety of methodologies; e.g. design and cloning of mammalian expression cassettes, PCR, DNA sequence interpretation, ELISA, western blot, viral growth curves, viral titers, transfections, virus purification
  • 4Excellent writing and communication skills; ability to understand and communicate scientific information; proficiency in Powerpoint, graphic displays and tables
  • 5A self-starter with the ability to work in a fast-paced environment and adapt quickly to changing needs and priorities; proven ability to prioritise and manage multiple tasks simultaneously.