- Job Title: Manufacturing Scientist – Cell and Gene Therapies
- Salary: Up to £38,000 dependent on experience, plus excellent benefits (bonus, pension (10% company contribution), private medical cover, life assurance plus others)
- Location: Central London
- Broad Role at the Cutting Edge of Research into the Manufacture of Cell & Gene Therapies Developing Manufacturing Protocols for use in Clinical Trials
Overview:
James Hume is currently recruiting for a Manufacturing Scientist to join a team that develops protocols for the manufacture of cutting edge cell and gene therapies. The company is leading the way in the development of cell & gene therapies by providing the multi - disciplinary expertise needed to bring these to the market. Their R&D Laboratories are in Central London, where this role will be based, and its purpose is to support the development of cell therapies to develop scalable clinical manufacturing protocols to eventually become suitable for commercial use.
The Company:
The company are a centre of excellence that is at the forefront of creating a viable and sustainable cell and gene therapy industry in the UK. Their headquarters are in central London where they have built a market leading multidisciplinary team that has the ability to take a therapy from concept through the development cycle to the market. They collaborate with both academia and industry and they are able to provide the scientific, clinical and commercial expertise needed to overcome the challenges that hinder the commercialisation of these fast developing, cutting edge technologies. Their longer term aim is to make the UK a global leader in the development and commercial exploitation of therapies. They are making great strides towards this aim with therapies entering phase 2 clinical trials and building credible cases to be progressed to stage 3. Added to this they are expanding their manufacturing and development operations to meet increased demand for their services from the academic and commercial sectors.
The Opportunity:
The Manufacturing Scientist role is broad with regular interaction with external collaborators to support the development of cell and gene therapies. Providing solutions to challenges faced during the manufacture of cutting edge technologies such as aseptic processing (manual processing or automated scale up of cell culture technologies), expansion harvest, and filling of cell therapy products. You will develop the manufacturing protocols for these novel products to then be transferred back to the collaborator.
This is a broad and challenging role where you will be able to use your science to overcome the hurdles faced in the commercialisation of cutting edge technologies. You will be working on a number of programmes at a time in an innovative, collaborative and flexible environment.
Desired Skills and Competencies:
For this opportunity you will need be educated to PhD or MSc level with the transferable skills for this role which are the culture of human and / or mammalian cell lines. Experience in the manufacture of biologics, cell or gene therapies or related novel medicines. You will need to have experience of Technology Transfer, and the writing of manufacturing protocols preferably to GMP regulations. With experience of working in an aseptic environment or aseptic processing.
Keywords
Process development, scale up, bio process, novel therapy, cell therapy, biologics, novel cell processing, FACS, flow cytometry, stem cell, upstream, downstream, GMP, GLP, GCP, cGMP, immune cell, lymphocytes, PBMC, dendritic, HSC CD34++, hESC, hiPS, MSC, cell isolation, flow cytometry, bioreactor, stirred tank, automation, robotics, 3d modelling, bioreactor, hollow fibre, primary cell isolation, cell activation, molecular biology, cell biology, flow cytometry, FACS, cell processing, allogenic, technology transfer, aseptic processing, tech transfer, cell culture, human, mammalian, protocol, expansion harvest, filling.