- Job Title: Process Development Scientist - Downstream
- Salary: Up to £40,000 D.o.E. plus benefits
- Location: Oxford
- Excellent Opportunity to Join a Cutting Edge Synthetic Biology Company Developing Solutions for the Cell and Gene Therapy industries.
Are you interested at working in an innovative and dynamic environment at the cutting edge of Synthetic Biology?
Do you have a proven track record of excellent research into downstream processes for mammalian production systems?
Are you a creative and rigorous thinker who can use your initiative to solve problems?
Then this is the opportunity for you!
Job Summary:
This is a truly exciting opportunity to join a fast developing biotech who are pioneers in the use of synthetic biology and its application to transform the discovery, development and manufacture of biologics, cell & gene therapies. Based in state-of-the-art laboratories near Oxford they are at the cutting edge of research in this field, which has huge potential to deliver solutions for the production of complex, high value products. They need to recruit a Process Development Scientist (Downstream) who can lead and deliver research projects in partnership with commercial organisations, alongside internal platform development projects that are crucial to the continued growth of the company.
The Company
The company are at the cutting edge of the exciting field of synthetic biology after developing their unique platform which enables them to offer solutions to the discovery, development and manufacture of biologics, cell & gene therapies. They currently offer a range of custom and platform services, specialising in DNA design, optimisation of protein and viral expression systems, and cell line development technologies.
A strong focus is placed on R&D activities and further developing platform technologies, as supported by the recent receipt of multiple grants awards from Innovate UK.
The Opportunity:
As the Process Development Scientist you will be focusing on the downstream processes of the internal and external research programmes developing production systems for therapeutic proteins and viral vectors. This is a dynamic role where you will be working in an innovative environment working closely with colleagues in relevant departments to identify and implement scalable processes for primary recovery and product purification.
This is a senior position within the laboratory team with the responsibility for planning and executing both internal and commercial research & development projects. You will be leading projects from the front by designing experimental programmes, mentoring technicians and driving forward projects to agreed milestones and deliverables. Using cutting edge technology such as TFF, ultracentrifugation, and AKTA based chromatography as well as others in your research. Then analysing the data generated from the work to continue to drive it forward and to be submitted in reports to the relevant internal and external stakeholders.
This company has fantastic growth potential meaning there will be opportunities to further your career, and to contribute significantly in bringing new products and services to the market.
Desired Skills and Experience:
They are looking for a creative thinking scientist who has a PhD or equivalent in a relevant field that has been followed by experience of downstream processes for mammalian systems for viral vector production. If you have experience of similar processes for protein production then this is advantageous to your application. You will need to have an engineering mindset with the ability to use statistical approaches with experience of using TFF and AKTA systems.
Keywords
Virus, viral, viral vector, bioprocessing, upstream, downstream, GMP, in vivo, ex vivo, gene therapy, cell therapy, vector, analytical development, scale up, bioprocess, biologics, bacteria, mammalian, human, primary, cell culture, industrialisation, commercialisation, engineering, bioreactor, chromatography, filtration, separation, purification, assay, characterisation, in process, control, biochemistry, molecular biology, cell line, mammalian, cell culture, synthetic biology, flow cytometry, recombinant protein, antibody, retrovirus, lentivirus, protein expression, robot, automation, bioreactor, manage, line management, matrix, protein, therapeutic protein, downstream, process development TFF, ultracentrifugation, AKTA based chromatography.