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Expired
  • Location: Oxford
  • Salary: Competitive
  • Job Type:Permanent

Posted about 2 months ago

  • Sector: Translational Science
  • Contact: James Hume
  • Contact Email: james.hume@nextphaserecruitment.com
  • Contact Phone: 01403 216216
  • Start Date: 2021-03-04
  • Job Ref: V-46671

This is a fantastic opportunity to join a progressive company who are developing an entirely new class of therapeutics.  By harnessing the natural delivery capabilities of exosomes to realise their potential using engineering and proprietary technologies.  Which addresses the short comings of other delivery methods because therapies can be delivered to cells and tissues that are out of reach to current methods including protein, antibody, and nucleic acid-based therapies.

They are seeking a Scientist to join their Viral Vector Process Development team which is expanding to meet the company’s growing ambitions and delivery of these life changing therapies.  What is key is that you will be using your scientific expertise in this role to actively influence the translation of the therapies.  This team also develops and transfers methods to internal CMC manufacturing teams as well as external parties.

Key Responsibilities:

  • Contribute to the development and optmisation of scalable commercial DSP processes to produce high quality novel viral vector products.

  • Provide technical & scientific leadership of downstream process development and transfer into CMC or GMP manufacture.

  • Contribute to the resolution of scientific and technical complications that do / could affect production.

  • Support the delivery of specific documentation for the platform and product e.g., reports and quality documentation.

  • Work in close collaboration with the R&D, Cell Line Development, DSP, Manufacturing Development and Quality Groups as a responsible member of the USP team.


Key Experience & Qualifications:

For this opportunity you will need:

  • A PhD or MSc / BSc in a relevant scientific area

  • Experience of working on Downstream Process Development and / or purification of Viral Vectors – e.g., AAV, Lentiviral, Adenoviral, and Retroviral

  • Experience of chromatography systems such as AKTA. With an understanding of other techniques such as IEX / SEC / HIC and Affinity

  • Expertise of analytical techniques such as SDS – Page and Western Blotting


Company Overview:

The company are privately held and are focused on harnessing the potential of exosomes because of the natural delivery capabilities and develop a new class of therapeutics.  Their mission is to positively impact human health, which is an ethos that drives all they do, to treat challenging diseases with limited treatment options.  They have the technology and ability to modify exosomes using their proprietary technology such as molecular engineering, drug loading, and targeting strategies.  With the purpose to facilitate the delivery of therapies to the areas of interest such as the brain and central nervous system. 

This approach addresses the short comings of other delivery methods because therapies can be delivered to cells and tissues that are out of reach to current methods including protein, antibody, and nucleic acid-based therapies.  To complement the science the company has a fantastic culture that invests in people but importantly the laboratories to ensure they stay at the forefront of the sector.  Offering a rewarding career at the cutting edge of science where you can develop your career over time as they continue to develop.