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Expired
  • Location: London, Greater London, England
  • Salary: Competitive
  • Job Type:Permanent

Posted about 2 months ago

  • Sector: Translational Science
  • Contact: James Hume
  • Contact Email: james.hume@nextphaserecruitment.com
  • Contact Phone: 01403 216216
  • Start Date: 2021-06-15
  • Job Ref: V-46899
A pioneering company who are at the centre of the Cell & Gene Therapy sector are seeking a Scientist to join their core R&D group based in Central London.   They are recruiting for a Scientist with a background in Next Generation Sequencing to support the translation of ATMP’s through the development of assays for characterisation and analytical development activities.

The Role of Scientist:

 As a Scientist you will be providing input into the design of experimental programmes and the execution of these with the purpose to support the translation of cell & gene therapies. You will be an integral member of the R&D team with a focus on the development of NGS and other assays for analytical development activities.

Responsibilities includes:

  • Working with autonomy design and conduct analytical development experiments using NGS protocols.
  • Contribute to the design of projects from an NGS and analytical perspective, working with the Senior and Lead Scientists to establish these.
  • Execute lab-based R&D projects applying your knowledge of NGS to develop analytical methods for the characterisation and analytical development projects..
  • Develop sequencing protocols for single cell RNAseq, gene editing and AAV product charcaterisation. 
  • Work with data scientists to deliver appropriate bioinformatic analysis through the provision of relevant technical and biological information.
  • Collaborate with other teams within the wider R&D Group.
  • Contribute to multiple Cell & / or Gene Therapies development projects at a time.
  • Contribute to the development of manufacturing processes to achieve scalable manufacturing protocols.
This is an excellent opportunity where you will be able to apply your science in an innovative environment at the cutting edge for develop of Cell & Gene Therapies with excellent career potential.

Required Skills and Expertise:

 

  • PhD or MSc in relevant area with additional experience.
  • Experience in the development and optimisation of Next Generation Sequencing (NGS)
  • Genome wide gene expression analysis.
  • Experience with sequencing methods for AAV vectors or other viral vectors is advantageous but not essential
  • Experience in the development of sequencing methods for gene editing is advantageous but not essential.
  • Experience of collaboration with bioinformaticians or handling raw NGS data is advantageous but not essential.
Company Overview:

 

The company’s aim is to advance the cell & gene therapy sector to make the UK the place to commercialise these life changing therapies.  They have the capabilities to take a therapy from the discovery phases, across the translational gap to the clinic and then through clinical trials to launch.  Using their R&D expertise to achieve this along with their drive for innovation and continuously adopting the latest and most effective approaches.  To complement their R&D efforts they have world class clinical operations, regulatory, health economics and market access expertise.  Added to this they have developed a unique and highly successful GMP manufacturing facility based in Stevenage where collaborators can manufacture their therapies for clinical trial and commercial use.

They have a strong culture that is focused on collaborative and innovative working to deliver these life changing therapies to patients.  As a company they offer excellent career development opportunities through their L&D programme that not only gives you the skills to advance your career but creates opportunities to take the step forwards to utilise them in a new position.  Added to this they are continuing to expand as the demand for their expertise increases and they explore new areas of the sector.