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  • Location: West London
  • Salary: Competitive salary with benefits package
  • Job Type:Permanent

Posted 7 days ago

  • Sector: Translational Science
  • Contact: Cameron Miskin
  • Contact Email:
  • Contact Phone: 01403 216216
  • Start Date: 2022-01-10
  • Job Ref: V-47148

A clinical stage T – Cell Therapy company who are pioneers in the sector with therapies advancing through clinical trials based on their proprietary technology for the reprogramming of T Cells.  They use this technology to engineer precisely targeted, specific and active T cell therapies that are capable of identifying cancels cells to then eliminate these.  They have an expanding pipeline of therapies with some at differing stages of clinical trials and others under development.  Added to this they are now constructing their own manufacturing facility to meet the changing and increasing needs of the company.

Role Overview:

They are continuing to develop and expand their Viral Vector teams who have the responsibility for the development and validation of scalable manufacturing processes.  For both lentiviral and retroviral vectors to be used in the clinic and for commercial supply.  As a Senior Scientist you will be a technical lead and viewed as a subject matter expert in the purification of viral vectors and apply this expertise across a range of developmental programmes to translate these to GMP manufacture.

This is an influential position where you will have the opportunity to shape and direct the Viral Vector group and the transition to GMP manufacture of these life changing therapies.  Working collaboratively to contribute to the development of processes suitable for the manufacture of retroviral and lentiviral vectors.  This includes small scale vector production, purification and analytical method development.

Responsibilities includes:

  • Be a key part in the development of strategies for viral vector process development.

  • Develop processes suitable for the purification of viral vectors.

  • Design and conduct experiments to characterise and optmise process parameters.

  • Plan DoE for viral vector purification.

  • Lead the tech transfer to Manufacturing Group.

  • Collaborate with different departments within the company for the development of processes.

  • Act as the Subject Matter Expert for in or more parts of viral vector process development

  • Co Author the CMC part of regulatory submissions to support regulatory filings such as IND and BLA’s

  • strategy development.

Desired Skills and Experience:

PhD or MSc in relevant scientific field

  • Relevant experience in the Downstream Process Development of Viral Vectors

  • Good understanding of cell biology, virology, and biochemistry

  • Experience in the purification of Viral Vectors.

  • Experience in the application of a range of biopharmaceutical and cell based techniques.

  • Experience in the mentorship / leadership of junior team members.

The Company

The company are a pioneering and ambitious Biopharmaceutical company who have developed next-generation, programmed T-cell therapies to treat haematological cancers and solid tumours. Scientifically, the company has extremely exciting technologies, using a broad suite of proprietary and modular T-cell programming to engineer precisely targeted, controlled and highly active T cells. Commercially, they have a pipeline of product candidates in development (for the treatment of haematological malignancies and solid tumours) and is increasing its GMP production capacity. Based in a state-of-the-art facility in Stevenage, Hertfordshire, you will join a team that is doing something genuinely meaningful.