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  • Location: London
  • Salary: Competitive
  • Job Type:Permanent

Posted 15 days ago

  • Sector: Translational Science
  • Contact: James Hume
  • Contact Email:
  • Contact Phone: 01403 216216
  • Start Date: 2021-10-07
  • Job Ref: V-47056
A clinical stage T – Cell Therapy company who are pioneers in the sector with therapies advancing through clinical trials based on their proprietary technology for the reprogramming of T Cells.  They are seeking a Senior Scientist Upstream Viral Vector Process Development to join the expanding team. They use this technology to engineer precisely targeted, specific, and active T cell therapies that are capable of identifying cancels cells to then eliminate these.  They have an expanding pipeline of therapies with some at differing stages of clinical trials and others under development.  Added to this they are now constructing their own manufacturing facility to meet the changing and increasing needs of the company.

Role Overview:

They are continuing to develop and expand their Viral Vector teams who have the responsibility for the development and validation of scalable manufacturing processes.  For both lentiviral & retroviral vectors and to be used in the clinic as well as for commercial supply.  As a Senior Scientist you will be a directing a small team and be responsible for the development and optimisation of upstream processes for manufacturing viral vectors.  Leading activities such as small & large scale bioreactor cell culture and scale up activities, delivery of adherent and suspended cell cultures.

Responsibilities includes:
  • Be a key part in the development of strategies for viral vector process development.
  • Develop process suitable for viral vector manufacture
  • Screening and determining the best conditions to produce viral vectors
  • Design and perform experiments to characterise and optimise critical process parameters.
  • Plan DoE experiments for viral vector production in small scale bioreactors and small flask.
  • Design and execute experiments that lead to the development and implementation of product and process improvements.
  • Analyse data from multiple experiments, develop conclusions, and determine future experiments.
  • Write reports to be used as part of regulatory submissions.
  • Lead the tech transfer to the Manufacturing Group.
 Desired Skills and Experience: 

  • PhD or MSc in relevant scientific field
  • Relevant experience of Upstream Process Development of Viral Vectors
  • Experience in academia or industry
  • Hands on experience of mammalian cell culture
  • Production experience at a small scale – bioreactor / shake flask
  • Good understanding of cell biology, virology, and biochemistry
  • Experience in the mentorship / leadership of junior team members.

The Company

The company are a pioneering and ambitious Biopharmaceutical company who have developed next-generation, programmed T-cell therapies to treat haematological cancers and solid tumours. Scientifically, the company has extremely exciting technologies, using a broad suite of proprietary and modular T-cell programming to engineer precisely targeted, controlled and highly active T cells. Commercially, they have a pipeline of product candidates in development (for the treatment of haematological malignancies and solid tumours) and is increasing its GMP production capacity. Based in a state-of-the-art facility in Stevenage, Hertfordshire, you will join a team that is doing something genuinely meaningful.