They are continuing to develop and expand their Viral Vector teams who have the responsibility for the development and validation of scalable manufacturing processes. For both lentiviral & retroviral vectors and to be used in the clinic as well as for commercial supply. As a Senior Scientist you will be a directing a small team and be responsible for the development and optimisation of upstream processes for manufacturing viral vectors. Leading activities such as small & large scale bioreactor cell culture and scale up activities, delivery of adherent and suspended cell cultures.
- Be a key part in the development of strategies for viral vector process development.
- Develop process suitable for viral vector manufacture
- Screening and determining the best conditions to produce viral vectors
- Design and perform experiments to characterise and optimise critical process parameters.
- Plan DoE experiments for viral vector production in small scale bioreactors and small flask.
- Design and execute experiments that lead to the development and implementation of product and process improvements.
- Analyse data from multiple experiments, develop conclusions, and determine future experiments.
- Write reports to be used as part of regulatory submissions.
- Lead the tech transfer to the Manufacturing Group.
- PhD or MSc in relevant scientific field
- Relevant experience of Upstream Process Development of Viral Vectors
- Experience in academia or industry
- Hands on experience of mammalian cell culture
- Production experience at a small scale – bioreactor / shake flask
- Good understanding of cell biology, virology, and biochemistry
- Experience in the mentorship / leadership of junior team members.
The company are a pioneering and ambitious Biopharmaceutical company who have developed next-generation, programmed T-cell therapies to treat haematological cancers and solid tumours. Scientifically, the company has extremely exciting technologies, using a broad suite of proprietary and modular T-cell programming to engineer precisely targeted, controlled and highly active T cells. Commercially, they have a pipeline of product candidates in development (for the treatment of haematological malignancies and solid tumours) and is increasing its GMP production capacity. Based in a state-of-the-art facility in Stevenage, Hertfordshire, you will join a team that is doing something genuinely meaningful.