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Expired
  • Location: Sandwich
  • Salary: Competitive rate
  • Job Type:Contract

Posted about 2 months ago

  • Sector: Translational Science
  • Contact: Gabby Boczon
  • Contact Email: gabby.boczon@nextphaserecruitment.com
  • Contact Phone: 01403 216216
  • Duration: 12 months
  • Start Date: 2021-10-03
  • Job Ref: V-47051

A graduate Post-doctoral Scientist is needed for an innovative pharmaceutical company based in Sandwich. The company's site in Sandwich plays a crucial role in transforming patients' lives by providing process technology, analytical methodology and support for the development and manufacture of medicines at all phases of clinical development. 

The company is seeking a graduate post-doctoral scientist whose main responsibility will be to further improve the understanding of the factors that can affect the rate and extent of formation of nitrosamine degradants in solid-state drug products. The right candidate will work with cross-functional development teams collaborating with organic chemists, formulation specialists, analytical chemists and material scientists. The right candidate will have strong track record in chemistry or analytical chemistry and will help to drive the project further through their insight and technical skills. 

This is a 12 month contracted position with a strong possibility of getting expended. On offer is a competitive hourly rate which will be discussed over the phone. 

Responsibilities of the graduate post-doctoral scientist:

. Collaborate with formulation and analytical scientists to study how the composition and solid-form properties of pharmaceutical products can affect nitrosamine formation.
. Design and execute accelerated stability studies and use statistical and kinetic modelling approaches to analyse the data and understand the effect of factors such as temperature and humidity
. Develop and apply quantitative trace analytical methods, especially LCMS, and apply a range of physical characterization techniques (such as laser diffraction, PXRD) as necessary.
. Effectively collaborate with project team members in a multidisciplinary environment (e.g. from analytical chemistry, material science, formulation science and organic chemistry), including presenting data at project team meetings, critically reviewing experimental data and be actively involved in solving technical challenges.
. Team interaction is critical, and the colleague must be able to collaborate with peers in a fast-paced, multi-disciplinary environment.
. May author internal and external publications and collaborate in cross-industry consortia on this topic.
. Provide presentations, training and advice to others to share learnings and promote increased scientific and technical understanding around their area of expertise.
. Devise creative solutions for reducing nitrosamine formation and develop experimental protocols to critically evaluate their effectiveness.
. Maintain written records of experimental work in accordance with GLP/GMP and departmental philosophies.

Qualifications:

  • Honours or Masters degree in Chemistry, Analytical Chemistry or a related discipline with a high degree classification (e.g. equivalent of U.K. 1st or 2nd class).

  • PhD degree in Chemistry, Analytical Chemistry, Pharmaceutical Sciences, Chemical Engineering, Material Science or a related field

Skills and Experience:

. A team orientated person with experience in a laboratory environment in the pharmaceutical industry or a closely related industry is highly desirable.
. Excellent team collaboration and organisational skills and ability to work in a multidisciplinary environment are also essential.
. A rational approach to problem solving with strong attention to detail and a desire to learn and grow their skills is essential.
. Experience of running quantitative high sensitivity LC-MS preferred
. Knowledgeable in the use of diverse computational, modelling and simulation tools would be highly beneficial.
. A good appreciation of small molecule pharmaceutical development and an ability to apply scientific technical skills and knowledge to projects independently and proactively.
. Able to demonstrate a good knowledge of contemporary analytical technologies.
. Experience in contributing to the authoring external technical publications is desirable.
. High level of practical competence with good laboratory safety awareness is expected.